PROCESS FOR PRF

Thursday, 22 March 1398 00:00
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PRF 

 PRF

The concept of PRF (Platelet Rich Fibrin) is based on the centrifugation of whole blood without anticoagulants. (J. Choukroun et al. 2001). At the end of the spin, a fibrin clot containing the majority of the platelets and white blood cells is obtained.

This fibrin clot called Platelet Riche Fibrin or PRF  will release gradually and growth factors or cytokines in the site (VEGF, PDGF, TGF Beta, Thrombospondin) .The expected objective of these growth factors is to accelerate the soft tissue and bone healing.Numerous international publications are available and demonstrate the effectiveness of PRF in many indications: oral surgery (implants, bone grafting, periodontal surgery, extractions, etc...), Orthopedic, cosmetic and dermatological surgery. Today, the PRF is recognized around the world, from Nice to New York from Los Angeles to Shanghai, from Rangoon to Moscow, from Sao Paulo to Cape Town, Santiago to Zagreb...

Its effectiveness is definitely proven.

 >INDICATIONS: 

Sinus lift                              Implants

Bone grafting                       Healing

Periodontology                     Extractions

 

ADVANCED PRF

Why Choukroun's  A-PRF™ ?

Many recent studies have shown the interest and potential of white cells in the inflammatory cascade, as a corollary, a prominent action in the early days of stimulation of osseo-progenitor cells. (Omar & Thomsen, Biomaterials, 2012, Kawazoe T, Cell. Transplant 2012) .It was therefore natural to try to capture the whole amount of monocytes in the PRF, to make it more active in stimulating bone grafts, but also to turn to a more rapid transformation of monocytes into macrophages to increase the effect bone stimulation.

This is done with the A-PRF™ or Advanced-PRF™.

> THE WHOLE PROTOCOL CHANGES !

The tubes, the centrifuge rpm and time of spin.

The first results of our research, conducted at the Laboratory of Clarion Research Group, Pennsylvania University (USA) and Repair-Lab, Institute of Pathology, Johannes Gutenberg University, Mainz (Germany) show a release of BMP-2 (Bone Morphogenetic Protein), and BMP-7. These studies also show a greater release of VEGF. Obviously, this release is from the monocytes. 

A specific tube that was developed following our scientific research and certified as Medical Device is the tube A-PRF™ +.  

This tube is the only authorized at this moment. Conventional tubes being used far tubes for laboratory tests and now non-regulatory. The tube A-PRF™ + is now available in sterile packed (May, 2013) .The first clinical data and results are very exciting! Many scientific studies are underway: The results will be published shortly. But the presence of BMP in sufficient quantity, already provides the A-PRF ™ a future by providing practitioners with a very powerful product for bone reconstruction and a still affordable

Education: The knowledge level of the teachers is not always at a good level. Dr Choukroun has already launched the concept of the PRF and A-PRF label education. This label is given to all practitioners who wish to be updated and to acquire the necessary knowledge to provide high quality education. Contact us to get the label.

> INDICATIONS: 

Sinus lift                            Implants

Bone grafting                     Healing

Periodontology                   Extractions

 

INJECTABLE -PRF

Numerous scientific publications describing the action of the white cells on vascularization and wound healing were published these recent years. With the unanimous conclusion that platelet concentrates enriched leukocytes are more effective on tissue and bone healing. The publication of our research on the A-PRF (PRF enriched leukocytes) and clinical outcomes confirm absolutely this scientific position.
However, the use of platelet concentrates in "liquid" and not coagulated remains an important indication in various medical and dental applications. That is why we have focused our research to a liquid "blood concentrate” enriched in white blood cells but also platelet-enriched to increase the healing properties while retaining the principle of centrifugation "without anticoagulants" or "no additives ".
The research was led by Dr Joseph Choukroun, the inventor of the PRF technique with  collaboration of two laboratories among the most renowned in the world (FORM in Frankfurt, Germany and Research Lab Clarion in Clarion, USA).

 

The result is the new protocol i-PRF !

Research of i-PRF ("i" as injectable) has been directed towards obtaining a blood concentrate with very high leukocyte content but which coagulates few minutes after the end of spin.
This "super PRF" is produced with new tubes i-PRF specific for this preparation.
The use of i-PRF is in its infancy, but already, the results in both oral surgery in regenerative medicine are very promising injection into soft tissue to increase vascularity and perhaps improve the biotype, injection into the bone graft particles (biomaterials) to coagulate and get a "solid" free of all movements granules.
The interest of the graft clot also lies in how to carve a bone graft and give it a compact form.
The protocol i-PRF is a real scientific and clinical innovation and will allow very many practitioners to improve their results in bone grafts.

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Nojan Daroo Sandos

Nojan Daroo Sandos Co., Produces High-Technology Products in the Special Treatment of Acute and Chronic Wounds and Also Exclusive Representative of Biogena Austria, France Process for PRF, Swiss SunStar Companies in Iran.

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